The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.

HaEmek Medical Center, Israel

Status: Completed

Conditions: Iron Deficiency Anemias

Study type: Observational

Funder types: Other

Identifiers

NCT02129907

thrombingeneration- anemia

Details and patient eligibility

About

In total 50 subjects with iron deficiency anemia treated with intravenous iron are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant before iron treatment. The investigators will measure the thrombin generation in plasma assessed by the calibrated automated thrombogram (CAT). patient will go face to face interview and will be asked to answer structured questionnaire which will include information on demographics, clinical data ( fever, allergies , etc.) and comorbidities

Two weeks after completing intravenous iron administration additional blood samples will be taken: thrombin generation will be measured

Enrollment: 82 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18 years
• Iron deficiency anemia that did not response to oral iron treatment and is planned to receive iron supplement intravenously.
• Signing the informed consent

Exclusion criteria

• chronic inflammatory disease
• renal failure
• Malignancy
• Infectious disease
• Other reason for anemia except iron deficiency anemia.
• Pregnant women
• Use of anti aggregating agents or anticoagulants