The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock (SepsisO2CO2R)

Avicenna Military Hospital

Status: Enrolling

Conditions: Septic Shock

Treatments: Diagnostic Test: PvCO2-PaCO2/CaO2-CvO2 ratio

Study type: Observational

Funder types: Other

Identifiers

NCT07096284

SEPSIS_CO2/O2_vs_lactate

Details and patient eligibility

About

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.

Full description

The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to compare the kinetics of the PvCO2-PaCO2/CaO2-CvO2 ratio with a classic marker of anaerobic metabolism (arterial lactate) in the early phase of septic shock.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients aged over 18 years presenting with septic shock, defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia > 2 mmol/L despite adequate fluid resuscitation. Sepsis is defined by the presence of a suspected or confirmed infectious source associated with organ dysfunction (neurological, respiratory, renal, hepatic, or hematological). [Sepsis 3 criteria]

Exclusion criteria

• Absence of central venous access.
• Central venous access not positioned in the superior vena cava (e.g., femoral access).

Trial design

30 participants in 1 patient group

Adult patients with septic shock.

Description:

Patients aged over 18 years presenting with septic shock. defined as sepsis with persistent hypotension requiring vasopressors to maintain a mean arterial pressure (MAP) ≥ 65 mmHg and lactatemia \> 2 mmol/L despite adequate fluid resuscitation.

Treatment:

Diagnostic Test: PvCO2-PaCO2/CaO2-CvO2 ratio