The Quality of Recovery From General Anesthesia With Desflurane for Fundus Surgery

Sichuan Provincial People's Hospital

Status and phase: Not yet enrolling; Early Phase 1

Conditions: Postoperative Recovery; Desflurane Anesthesia

Treatments: Drug: Desflurane Inhalant Product

Study type: Interventional

Funder types: Other

Identifiers

NCT06241131

2023-501

Details and patient eligibility

About

The goal of this clinical trials to study and compare the effects of "desflurane with remifentanil anesthesia (study group)" and "sevoflurane with remifentanil anesthesia (control group)" for elective fundus surgery anesthesia. The main question it aims to answer are the characteristics of desflurane anesthesia in patients undergoing fundus surgery and to provide universal guidance for clinical application.

Enrollment: 220 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ASA I-II, patients aged 18-65 years old;
2. Fundus surgery to be performed under general anesthesia ;
3. The expected duration of surgery is about 30-120 min ;
4. BMI: 18-30 kg/m2 ;
5. Those who signed the informed consent form and volunteered to participate in this trial

Exclusion criteria

1. Patients with known or suspected genetic susceptibility to malignant hyperthermia;
2. Patients with history of asthma;
3. Patients with severe heart diseases (NYHA ≥ III, severe arrhythmia, etc.) and cerebral or pulmonary diseases, liver or kidney dysfunction; or with unstable vital signs;
4. Patients with history of long-term narcotic analgesics application, including sedative and antidepressant drugs;
5. Patients with history of psychotropic drug abuse within 3 months;
6. Patients with long-term alcohol abuse;
7. People with mental disorder and unable to communicate normally;

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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220 participants in 2 patient groups

desflurane with remifentanil anesthesia

Experimental group

Description:

Subjects were randomly assigned to the experimental group。In this group, desflurane was inhaled at a starting concentration of 1 MAC (Minimal Alveolar Concentration), and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.

Treatment:

Drug: Desflurane Inhalant Product

sevoflurane with remifentanil anesthesia

Active Comparator group

Description:

Subjects were randomly assigned to the active comparator group。In this group, sevoflurane was inhaled at a starting concentration of 1 MAC, and remifentanil 0.1 μg/kg/min was continuously pumped intravenously.

Treatment:

Drug: Desflurane Inhalant Product