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The Rate of C-reactive Protein (CRP) Increase as a Marker for Bacterial Infections in Children (CRPv)

S

Shaare Zedek Medical Center

Status

Unknown

Conditions

Viral Infection
Bacterial Infections

Study type

Observational

Funder types

Other

Identifiers

NCT01159470
472010.ctil

Details and patient eligibility

About

Fever is one of the most common problems in pediatrics. Differentiating between bacterial infections, that require antibiotic therapy, and viral infections that resolve on their own is an important challenge for physicians.

C-reactive protein (CRP) is a protein that increases in response to inflammation and its level is generally higher in bacterial infections compared to viral infections. it can be measured by a simple blood test, however its utility as a sole marker for bacterial infection is limited.

The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by the hours since the fever started will improve the utility of CRP for the diagnosis of bacterial infections in children.

Enrollment

200 estimated patients

Sex

All

Ages

Under 5 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • children less than 5 years of age,
  • children with no comorbidities and fever > 38 for at least 24 hours, and
  • children with no previous antibiotic therapy.

Exclusion criteria

  • HIV,
  • immunosuppressive conditions,
  • antibiotic therapy.

Trial design

200 participants in 2 patient groups

bacterial infection
Description:
children with fever due to bacterial infection
viral infection
Description:
children with fever due to viral infection

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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