The Ratio of Hypnotic to Analgesic Potency of Volatile Anesthetics

Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Status and phase

Completed

Phase 3

Conditions

Anesthesia

Treatments

Drug: Sevoflurane

Drug: Isoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT03588429

2018CZTCWM

Details and patient eligibility

About

The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.

Full description

Anesthetic agents vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different spectral entropy or bispectral index values. However, there is no study that demonstrate the difference between analgesic potency of volatile anesthetics. The aim of this clinical trial is to evaluate the ratio of hypnotic to analgesic potency of sevoflurane and isoflurane at equi-minimum alveolar concentration using EEG analysis.

Enrollment

90 patients

Sex

All

Ages

19 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing general anesthesia using volatile anesthetics and intubation
patients with american society of anesthesiologist physical status I, II
patients obtaining written informed consent

Exclusion criteria

patients with a history of any psychiatric or neurological disease
patients who had received any medication affecting the central nervous system
patients who had received medication affecting the sympathetic or parasympathetic nervous systems
patients undergoing supraglottic airway for airway management
pregnant women