The REALITY Study - Head-to-Head Comparison Between Cypher and Taxus

Cordis

Status and phase: Completed; Phase 4

Conditions: Coronary Artery Disease

Treatments: Device: Cypher Sirolimus-Eluting Stent; Device: Taxus Paclitaxel-Eluting Stent

Study type: Interventional

Funder types: Industry

Identifiers

NCT00235092

EC03-02

Details and patient eligibility

About

The main objective of this study is to compare the performance of the Cypher sirolimus-eluting and the Taxus paclitaxel-eluting stent systems in a prospective, multi-center, randomized clinical study.

Full description

This is a prospective, randomized study conducted at 90 centers in Europe, Latin-America and Asia. A total of 1335 patients will be entered into the study and will be randomized on a 1:1 basis to either the sirolimus-eluting or the paclitaxel-eluting stent system. All patients will have repeat angiography at eight months and will be followed for 24 months post-procedure.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Diagnosis of angina pectoris as defined by Canadian Cardiovascular Society Classification (CCS I, II, III, IV) OR unstable angina pectoris (Braunwald Classification B&C, I-II-III) OR patients with documented silent ischemia;
2. Treatment of up to two de novo native coronary artery lesions in a maximum of two major coronary arteries;
3. Ostial lesions;
4. Bifurcations;
5. Target vessel diameter of both lesions must be >=2.25mm and <=3.0mm in diameter (visual estimate);
6. One target lesion must be at least 15 mm in length and the second lesion has to be at least 10 mm in length with no upper limit on either;
7. Target lesion stenosis for both lesions is >50% and <100% (visual estimate).

Exclusion criteria

1. Patient has experienced a Q-wave or non-Q-wave myocardial infarction with documented total CK >2 times normal within the preceding 72 hours and the CK and CK-MB enzymes remain above normal at the time of treatment;

2. Has unstable angina classified as Braunwald A I-II-III;

3. Any of the lesions is an unprotected left main coronary disease with >=50% stenosis;

4. Angiographic evidence of thrombus within target lesion;

5. Heavily calcified lesion and/or calcified lesion, which cannot be successfully predilated (applies to both lesions);

6. Documented left ventricular ejection fraction <=25%;

7. Totally occluded vessel (TIMI 0 level) (applies to both lesions);

8. Prior stent within 10mm of target lesion (applies to both lesions).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)