The Regulation of Pulmonary Vascular Resistance in Patients With Heart Failure (PVR)

University of Toledo Health Science Campus

Status: Completed

Conditions: Diastolic Heart Failure; Pulmonary Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT02275793

PVR

Details and patient eligibility

About

Peripheral blood and blood following a pulmonary wedge pressure will be obtained from patients undergoing right heart catheterizations.

Full description

It is well known that left sided heart disease can lead to pulmonary hypertension via a number of proposed mechanisms. The purpose in this study is to identify biomarkers in pulmonary hypertension to further understand the pathophysiology of this disease in patients with heart disease.Patients are recruited in the cardiac catheterization lab, which are undergoing right heart catheterization as per their plan of care established by their primary cardiologist. During the procedure, we will ask the performing cardiologist to obtain a blood sample of 40-50 milliliters from the catheter that they are using during the procedure. These blood samples will be sent for analysis of biomarkers. The patient will then have an echocardiogram done 1 year from their heart catheterization.

Enrollment: 90 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years
• Ability to provide informed consent.
• Presenting for cardiac catheterization for evaluation of heart disease
• Ejection Fraction > 50%

Exclusion criteria

• Unable to provide informed consent.
• Unable or unwilling to comply with the protocol and follow up.
• Infiltrative cardiomyopathy
• Constrictive pericarditis
• Severe valvular disease
• Comorbid status with life expectancy <3 years
• Right ventricular dysplasia
• Congenital heart disease
• On immunosuppressive drugs.
• Patients who has heart transplant.
• Ejection Fraction < 50%
• Mean Pulmonary Artery Pressure <25
• Wedge pressure <15

Trial design

90 participants in 3 patient groups

high PH and normal PVR

Description:

Group I, diastolic heart failure with high PH and normal PVR

high PH and high PVR

Description:

Group II, diastolic heart failure with high PH and High PVR

normal PH and normal PVR

Description:

Group III, no heart failure, normal PH and normal PVR