The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis

Eskisehir City Hospital

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Diagnostic Test: knee ultrasonography

Study type: Interventional

Funder types: Other

Identifiers

NCT04779164

EskCityHosp

Details and patient eligibility

About

Background:Knee osteoarthritis is more common in patients with type-2 diabetes mellitus, however it is not known whether this effect is caused by diabetes itself or concominant abdominal obesity.

Objectives:The aim of this study is to determine whether type-2 diabetes itself, independent of abdominal obesity, is a risk factor for femoral cartilage, knee osteoarthritis and poor quality of life.

Design:A cross-sectional design. Settings:Training and research hospital in Turkey. Patients and Methods:Female patients was enrolled in this study and divided into two groups: according to presence or absence of diabetes. Later, both the patients with and without abdominal obesity was divided into two groups according the presence of diabetes.

Main Outcome measures:Clinical parameters were visual analog-scale, gait speed and short form-36. Knee radiographs were evaluated according to Kellgren Lawrance-Scale. And ultrasonography parameters were the measurements of distal femoral cartilage thickness.

Sample size:126

Enrollment: 126 patients

Sex: Female

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• being female
• aged between 40 and 70.

Exclusion criteria

• Patients with any concomitant chronic disease
• rheumatoid arthritis
• cardiac diseases (except type 2 diabetes mellitus and hypertension)
• knee surgery
• trauma
• bone mass or cancer
• inflammatory arthritis
• impaired cognitive status
• immobilized patients
• type 1 diabetes mellitus

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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126 participants in 2 patient groups

Patients with type 2 diabetes

Experimental group

Description:

Patients with diabetes mellitus was evaluated in terms of pain scores and ultrasonographic femoral cartilage thickness and retrospective radiographic knee osteoarthritis scores.

Treatment:

Diagnostic Test: knee ultrasonography

Patients without type 2 diabetes

Other group

Description:

Patients without diabetes mellitus was evaluated in terms of pain scores and ultrasonographic femoral cartilage thickness and retrospective radiographic knee osteoarthritis scores.

Treatment:

Diagnostic Test: knee ultrasonography