The Relation Between MiR-125b-5p and Staging of Endometriosis

Tanta University

Status: Completed

Conditions: Endometriosis

Treatments: Diagnostic Test: Blood sampling; Procedure: laparoscopic examination

Study type: Interventional

Funder types: Other

Identifiers

NCT05556213

35617/8/22

Details and patient eligibility

About

78 endometriosis patients presented with infertility were clinically examined and the diagnosis was assured by US imaging. The study also included 11 control fertile women free of gynecological problems as a control for lab tests. Patients and controls gave blood samples for lab investigations. All patients underwent diagnostic abdominal laparoscopy under general anesthesia for disease staging. Quantitative determination of expression levels of genes of microRNA-125b-5p and 203a was conducted using qRT-PCR.

Enrollment: 89 patients

Sex: Female

Ages: 22 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who presented clinical pictures suggestive of EM disease

Exclusion criteria

• Patients with previous pelvic or abdominal surgery that may hinder the laparoscopic examination,
• patients who were suspicious of having malignancy elsewhere in the body region,
• pregnant women,
• patients who had diabetes mellitus,
• body mass index (BMI) of >30 kg/m2, coagulopathies, and autoimmune disorders.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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89 participants in 2 patient groups

Patients

Active Comparator group

Treatment:

Procedure: laparoscopic examination

Control

Active Comparator group

Treatment:

Diagnostic Test: Blood sampling