The Relation Between Uric Acid Level and Endothelial Dysfunction in Patients With Polycystic Kidney Disease

TC Erciyes University

Status: Terminated

Conditions: Polycystic Kidney, Autosomal Dominant

Study type: Observational

Funder types: Other

Identifiers

NCT01589705

Erciyes 2011/273

Details and patient eligibility

About

There are substantial data demonstrating increased endothelial dysfunction, inflammation and oxidative stress in patients with Autosomal dominant polycystic kidney disease (ADPKD), the association between serum uric acid level and endothelial dysfunction has not been elucidated yet in these patients. Therefore, in this study, the investigators aimed to examine the relationship between the uric acid level and the ED in normotensive ADPKD patients with preserved renal function.

Full description

This is the first study to evaluate the relationship between uric acid and endothelial dysfunction in patients with early stage ADPKD

Enrollment: 150 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ADPKD patients with normal renal function,
• Normotensive ADPKD patients

Exclusion criteria

• Patients with impaired kidney function,
• Atherosclerotic disorders,
• Diagnosis of hypertension, gout, diabetes,
• Using of insulin, thiazide, allopurinol or uricosuric drugs

Trial design

150 participants in 1 patient group

polycystic kidney ,no hypertension

Description:

The study evaluated the association of serum uric acid levels with endothelial dysfunction in early ADPKD patients with normal renal function