The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome

Ain Shams University

Status: Completed

Conditions: Polycystic Ovarian Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT02869750

ADIPCOS

Details and patient eligibility

About

To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).

Full description

Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups

Enrollment: 300 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital

Exclusion criteria

• Known androgen secreting tumor.
• PCO on ovarian stimulation medications
• PCO with any other medical illness.

Trial design

300 participants in 4 patient groups

Obese PCOS

Description:

PCOS patients with BMI more than 25 kg/m2

Lean PCOS

Description:

PCOS patients with BMI less than 25 kg/m2

PCOS with normal HOMA2-1R

Description:

PCOS without Insuline resistance

PCOS with elevated HOMA2-IR

Description:

PCOS with Insuline resistance