The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays

Taipei Medical University

Status: Completed

Conditions: Developmental Delays

Treatments: Other: study group

Study type: Observational

Funder types: Other

Identifiers

NCT02523989

SKH-TMU-100-06

Details and patient eligibility

About

The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.

Full description

The investigators recruited children with developmental delays and children with normal development from Shin-Kong Ho-Su Memorial Hospital as controls. Information obtained from the interview included socioeconomic and basic demographic characteristics as well as children function, health condition, and quality of life. On the other hand, blood and urine samples of the participants were collected for the analysis of arsenic methylation related enzymes using polymerase chain reaction and restriction fragment length polymorphism. 2 ml blood were digested for the determination of mercury, lead and arsenic. The relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of were analyzed.

Enrollment: 137 patients

Sex: All

Ages: 2 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Study group:

Inclusion Criteria:

• children with developmental delays obtained written informed consent from parents

Exclusion Criteria:

• parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents

Control group:

Inclusion Criteria:

• children with normal development obtained written informed consent from parents

Exclusion Criteria:

• parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents

Trial design

137 participants in 2 patient groups

study group

Description:

children confirmed to have developmental delays

Treatment:

Other: study group

control group

Description:

children with typical development

Treatment:

Other: study group