The Relationship Between Arterial Stiffness and Hemodynamic Responses in Patients With Spinal Anesthesia (SpiASHT)

Aydin Adnan Menderes University

Status: Completed

Conditions: Hypertension; Spinal Anaesthesia; Arterial Stiffness

Treatments: Procedure: PWV

Study type: Observational

Funder types: Other

Identifiers

NCT05537246

SpiASHT

Details and patient eligibility

About

The aim of this study is to investigate the importance of pulse wave velocity, an indicator of arterial stiffness, in predicting hemodynamic changes in normotensive and hypertensive patients undergoing spinal anesthesia.

Full description

The prospective cross-sectional study will be carried out between September 1, 2021 and September 1, 2022 at Aydin Adnan Menderes University Faculty of Medicine. Patients aged eighteen and over who will undergo lower extremity surgery under spinal anesthesia will be included in the study.

During the preoperative evaluation, the patient will be asked about age, weight, height, smoking and alcohol use history. At the same time, hypertension disease (if any, drugs used), diabetes (if any, drugs used), hyperlipidemia (if any, drugs used) and other diseases and drugs used will be recorded.

Before surgery, hemodynamic data (systolic arterial blood pressure, diastolic arterial blood pressure, mean arterial blood pressure, heart rate and oxygen saturation), arterial stiffness measurement (pulse wave velocity) will be evaluated in the patient preparation room. Arterial stiffness measurement will be made with the oscillometric mobil-o-graph device in the anesthesia department.

Hemodynamic data is recorded by the anesthesia device 1.,3.,5.,10.,20. minutes during surgery. Intraoperative hypotension is accepted as a 20% reduction in systolic arterial blood pressure evaluated before anesthesia. Using this data recorded on the monitor, reductions of 20% or more in systolic arterial blood pressure will be recorded as hypotension.

Enrollment: 124 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing elective lower extremity surgery
• 18 years and over
• who agreed to participate in the study
• ASA I-II

Exclusion criteria

• Undergoing cardiovascular or neurological surgery within 6 months
• Unwilling to participate in the study
• Undergoing prosthetic valve surgery
• Vasculitis
• Peripheral artery disease
• Under the age of 18
• Conditions in which spinal anesthesia is contraindicated

Trial design

124 participants in 2 patient groups

GROUP HT

Description:

In the preoperative evaluation, after arterial blood pressure measurement was made 3 times; Hypertension group was defined as the patients who did not use drugs that are effective on the cardiovascular system, whose SBP value was higher than 140 mmHg, or those who were diagnosed with hypertension and were using drugs with a SBP value higher than 140 mmHg.

Treatment:

Procedure: PWV

GROUP NORMO

Description:

As a result of 3 measurements and medical histories of the cases, those who did not use drugs effective on the cardiovascular system and whose SBP value was lower than 140 mmHg were called the normotensive group.

Treatment:

Procedure: PWV