The Relationship Between CD138 Count of Endometrium and Reproductive Outcome

Reproductive & Genetic Hospital of CITIC-Xiangya

Status: Completed

Conditions: Infertility

Treatments: Procedure: Endometrial biopsies

Study type: Interventional

Funder types: Other

Identifiers

NCT03689101

P2018009

Details and patient eligibility

About

It's well known, endometritis affects reproductive outcomes. Though CD138 counting as one new diagnosis measure for endometritis, diagnostic criterion of this measure isn't consistent. And if the CD138 counting is correlation to the outcome of reproductive is not clear.

Firstly, This study aims to explore the relationship between endometrial CD138 count and pregnancy outcome following frozen embryo transfer in natural cycles. Secondly , the investigators want to find a cut-off value which is related to reproduction outcome.

Enrollment: 148 patients

Sex: Female

Ages: 20 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between20 and 38 years;
• regular menstrual cycles;
• body mass index (BMI) ranged from 18 to 25

Exclusion criteria

• uterine abnormalities;
• intrauterine adhesions（moderate - severe）, advanced endometriosis, adenomyosis, untreated hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm and/or endometrial pressure)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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148 participants in 1 patient group

Endometrial biopsies

Experimental group

Description:

Endometrial biopsy was performed precisely 7 days after LH surge (LH+7) to count endometrial CD138.

Treatment:

Procedure: Endometrial biopsies