The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery

Pomeranian Medical University Szczecin

Status: Completed

Conditions: Delirium - Postoperative; CABG; BDNF

Study type: Observational

Funder types: Other

Identifiers

NCT06967779

delirium CABG

Details and patient eligibility

About

This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury induced by cardio-pulmonary by-pass and its association with genetic predisposition in patients undergoing coronary artery bypass grafting (CABG) carrying BDNF gene polymorphism (Val66Met).

Enrollment: 107 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria include:

1. Age > 18 years.
2. Planned coronary artery bypass grafting (CABG) procedure with the use of cardiopulmonary by-pass (CPB).
3. Ability to understand and sign an informed consent form.

Exclusion criteria include:

1. Emergency surgery.
2. Previous known cognitive disorders: Mini Mental State Examination (MMSE) score <15.
3. Baseline delirium (positive CAM test prior to surgery).
4. Diagnosis of psychiatric syndromes in the past - i.e. depression, dementia, psychosis or schizophrenia.
5. Inability to understand Polish language.
6. Inability to give and sign informed consent due to auditory or visual dysfunction.