The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation

Inonu University

Status: Completed

Conditions: Liver Transplant; Complications; HLA Antigens

Treatments: Other: HLA antigen results

Study type: Observational

Funder types: Other

Identifiers

NCT04885582

2017/133

Details and patient eligibility

About

Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates depending on the experience gained, the most common biliary complications did not improve at the desired level. For this reason, studies in this field are frequent today.

The structural complexities of HLA antigens have been the subject of investigation in recent years. With the development of DNA and RNA amplification methods; It is increasingly difficult for physicians to keep up with the increasing burden of knowledge regarding the genetic aspects of these antigens. Concrete benefits of this gene complex, which has been investigated in various fields and preserves its mystery, have not been determined in liver transplant patients. However, there are publications showing its connection with the bile epithelium in liver transplantation and its relationship with the disappearing bile duct syndrome. In this study, our aim is to explain whether the bile duct complications, which appear like a continuous wall and can lead to frightening pictures, are related to HLA tissue compatibility.

Enrollment: 80 patients

Sex: All

Ages: 1 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with liver transplantation and tested for HLA antigen (recipient - donor)

Exclusion criteria

• patients who died early Patients whose HLA antigen is not checked

Trial design

80 participants in 2 patient groups

Patients with biliary complications

Description:

patients with postoperative biliary fistula, biliary stenosis

Treatment:

Other: HLA antigen results

Patients without biliary complications

Description:

patients without postoperative biliary fistula and biliary stenosis

Treatment:

Other: HLA antigen results