The Relationship Between Inflammatory ARTritis and CArdiac DIseAse (ARTCADIA)

University Hospital, Gentofte, Copenhagen

Status: Active, not recruiting

Conditions: Heart Failure, Diastolic; Valvular Heart Disease; Stroke; Cardiac Disease; Left Ventricular Systolic Dysfunction; Inflammatory Arthritis; Myocardial Infarction; Heart Failure; Axial Spondyloarthritis; Ischemic Heart Disease; Heart Failure, Systolic; Myocardial Dysfunction; Spondyloarthritis; Spondylitis, Ankylosing; Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT05647577

H-20023771

Details and patient eligibility

About

The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to collectively as inflammatory arthritis (IA). The main questions it aims to answer are:

• Using conventional echocardiography, the investigators aim to determine the prevalence of overt and asymptomatic cardiac dysfunction in a large random sample of outpatients with IA. Cardiac dysfunction will be evaluated by echocardiography and cardiac biomarkers (NT-pro-BNP, hs-TNT and hs-CRP).
• In patients without known heart disease: Using 2, 5 and 10 year follow-up, the investigators aim to examine if advanced echocardiography can be used to detect early signs of heart disease by investigating the clinical significance of adding deformation measures - alone and in combination with selected biomarkers - to conventional risk factors in the cardiac risk assessment of patients with IA

Participants will undergo an echocardiographic examination in combination with a general health assessment including obtainment of cardiac biomarkers and a electrocardiogram.

Using advanced echocardiography - Tissue Doppler Imaging, 2- dimensional speckle tracking echocardiography, 3D-echocardiography and 3-dimensional speckle tracking echocardiography - the investigators also aim to compare myocardial deformation parameters of patients with IA to a gender and age matched control group without IA from the Copenhagen City Heart Study.

Enrollment: 1,285 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Persons with a diagnosis of with a confirmed diagnosis of rheumatoid Arthritis or axial spondyloarthritis

Exclusion criteria

• Persons not able to cooperate
• Persons unable understand and sign "informed consent"

Trial design

1,285 participants in 2 patient groups

Inflammatory arthritis patients

Description:

Patients with an confirmed diagnosis of rheumatoid arthritis or axial spondyloarthritis.

Participants from the general population

Description:

Patients with inflammatory arthritis will be compared to community-dwelling individuals from the 4th and 5th examination round from the Copenhagen City Heart Study (ClinicalTrials.gov identifier NCT02993172, I-Suite no. 03741, National Committee on Health Research Ethics approval HEH-2015-045).