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The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

T

Taipei Medical University

Status

Unknown

Conditions

Candidemia Prognostic Factor and Mycobiological Analysis.

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C. albicans causing candiuria disclosed that renal insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of treatment failure. However, we also found results of E-test drug susceptible test could not predict outcome. Hence, retrospective analysis of 31 months period, cases that had C. albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological study and potential virulent gene analysis.

This study is designed to clarity the clinical meaning of morphological form and virulent genes on candidemia. To do this study is probably helpful for treatment of candidiasis.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 2007 to 2010 medical records
  • Cases with candidemmia of Candida albicans with available clinical information in medical records for analysis.
  • Cases with candidemmia of Candida albicans which clinical isolates were preserved.

Exclusion criteria

  • Cases were not hospitalized for treatment and data were not available for analysis.

Trial contacts and locations

1

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Central trial contact

Tsong-Yih Ou

Data sourced from clinicaltrials.gov

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