The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

Taipei Medical University

Status: Unknown

Conditions: Candidemia Prognostic Factor and Mycobiological Analysis.

Study type: Observational

Funder types: Other

Identifiers

NCT01211041

99026

Details and patient eligibility

About

Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C. albicans causing candiuria disclosed that renal insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of treatment failure. However, we also found results of E-test drug susceptible test could not predict outcome. Hence, retrospective analysis of 31 months period, cases that had C. albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological study and potential virulent gene analysis.

This study is designed to clarity the clinical meaning of morphological form and virulent genes on candidemia. To do this study is probably helpful for treatment of candidiasis.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 2007 to 2010 medical records
• Cases with candidemmia of Candida albicans with available clinical information in medical records for analysis.
• Cases with candidemmia of Candida albicans which clinical isolates were preserved.

Exclusion criteria

• Cases were not hospitalized for treatment and data were not available for analysis.