The Relationship Between Motor Cortex Oxygenation and Motor Function Recovery in Stroke Patients

Kaohsiung Veterans General Hospital

Status: Completed

Conditions: Stroke

Treatments: Other: Rehabilitation programs; Procedure: Functional Electric Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01781689

VGHKS102-086

VGHKS12-CT7-07 (Other Identifier)

Details and patient eligibility

About

Stroke is the most common cause of motor function impairment. However, the functional impairment is not totally irreversible. Several mechanisms may involved in both the cortical and motor function recovery after onset of stroke, and most of them are related to changes of cortical perfusion and metabolism.

Motor function recovery after stroke (especially middle cerebral artery territory lesion) frequently follow stereotypic pattern (brunnström stage).

This study is designed to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke. To seek if there is similar stereotypic pattern of motor cortex oxygenation/metabolism change during the recover stage after stroke.

Full description

Participants receive evaluations (1/week for 3 months period) of

• motor function (Include: MMSE, brunnström stage, Fugl-Meyer Assessment of Physical Performance, Box and Block Test of Manual Dexterity, Functional Independence Measure)
• cortical perfusion detection during performing limb movements (using NIRS)

Then use path analysis to investigate the relationship between motor cortex oxygenation/metabolism and motor function recovery after stroke.

Enrollment: 10 patients

Sex: All

Ages: 45 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ischemic stroke(unilateral, onset within 7 days, without previous stroke history)
• Vital sign stable
• Upper extremity motor function impairment(brunnström stage I~III)

Exclusion criteria

• with pacemakers
• Seizure history
• Serious dysrhythmias
• Poor cognition function(MMSE<13)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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10 participants in 3 patient groups

Functional Electric Stimulation

Experimental group

Description:

perform arm cranking with functional electrical stimulation

Treatment:

Procedure: Functional Electric Stimulation

traditional rehabilitation program

Sham Comparator group

Description:

Receive traditional rehabilitation programs

Treatment:

Other: Rehabilitation programs

Health

No Intervention group

Description:

with no motor function impairment