The Relationship Between Neuropathic Complaints and Central Sensitization in Fibromyalgia

Marmara University

Status

Enrolling

Conditions

Fibromyalgia

Neuropathic Pain

Central Sensitisation

Treatments

Other: Fibromyalgia impact questionnaire

Diagnostic Test: Symptom severity scale

Diagnostic Test: Hospital Anxiety and Depression Scale

Diagnostic Test: Widespread pain index

Diagnostic Test: Central sensitization inventory

Diagnostic Test: Self-Leeds Assessment of Neuropathic Symptoms and Signs

Study type

Observational

Funder types

Other

Identifiers

NCT05701696

22/640

Details and patient eligibility

About

Fibromyalgia (FM) is the prototype of a group of diseases known as central sensitivity syndromes, whose relationship with pain sensitization is well defined. Central sensitization (CS) is also one of the mechanisms involved in the pathophysiology of neuropathic pain. Neuropathic pain, which is a common complaint in FM patients, is likely to be one of the clinical manifestations of central sensitization. Therefore, in this study, it was aimed to investigate the relationship between CS and neuropathic pain.

Full description

The term central sensitization (CS) was first used by Wolf in 1988 and explained as an increase in pain sensitivity with the amplification of neuron-derived signals in the central nervous system. Fibromyalgia (FM) is a disease characterized by chronic widespread pain and its etiology and pathophysiology are still unknown. It is considered to be the main member of the CS related disease group known as central sensitivity syndromes with impaired pain regulation. In various studies, hyperalgesia and allodynia, which are accepted as objective findings of CS in pain sensitization. In addition to widespread body pain, neuropathic pain is one of the common symptoms in FM, and various studies have shown a significant increase in neuropathic pain in FM patients compared to healthy controls. It is known that CS is one of the basic mechanisms in the etiopathogenesis of neuropathic pain as well as its role in FM. In a study of FM patients, painDETECT and S-LANSS scores were found to be correlated with CSI scores, and the authors emphasized the relationship between pain sensitization and neuropathic complaints in these patients. CS seems likely to be one of the neuropathic pain mechanisms in FM patients, and the available data seem insufficient to draw a definitive conclusion. From this point of view, in this study, it was aimed to investigate the relationship between the presence and severity of CS and the neuropathic pain component of the disease in patients with FM.

Enrollment

111 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosing fibromyalgia according to ACR 2016 criteria
Between the ages of 18-65
Agree to participate in the study

Exclusion criteria

History of concomitant systemic inflammatory disease, active infection and malignancy
Refusing to participate in the study
Polyneuropathy, entrapment neuropathy, and radiculopathy are other diagnosed sources of neuropathic pain.