The Relationship Between NK Cell and Graves' Disease

Shandong First Medical University

Status: Unknown

Conditions: Graves Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04135573

2018109

Details and patient eligibility

About

Graves' disease (GD) is one of organ specific autoimmune diseases, the pathogenesis is not elucidated.Natural Killer (Natural Killer, NK) cells is a kind of important immune regulator, several abnormalities of NK cell function and number in GD patients have been described in the investigators' previous study. It is remain unclear whether the NK cell disfunction is a consequence of GD.Based on the investigators' previous study, the investigators plan to monitor NK cell function in participants in the whole course of disease, analyze the association with relevant factors, such as thyroid function, immune state or treatment,to find out influences of thyroid hormones and thyroid receptor antibody affecting the function of NK cell. The investigators will reveal whether the disfunction of NK cell secondary to GD abnormal thyroid function and/or immune disorders, and realize the mechanics.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• New GD patients without any treatment
• Aged of 18 to 75 years old

Exclusion criteria

• Pregnant or lactating woman;
• Known autoimmune disease;
• Receiving psychotropic or hormonal drugs;
• Taking drugs that affect the body's immune function;
• Obviously poor compliance.

Trial design

200 participants in 2 patient groups

New untreated GD patients

Description:

Before treatment and application of anti-thyroid drugs (methimazole) or radioactive iodine treatment

Healthy control

Description:

No thyroid related diseases and other immune diseases