The Relationship Between NLR and PONV and ESPB

Qianfoshan Hospital

Status and phase: Not yet enrolling; Phase 1

Conditions: Erector Spinae Plane Block; Neutrophil to Lymphocyte Ratio

Treatments: Procedure: 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB).; Procedure: Erector Spinae Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT06127966

YXLL-KY-2023（101）

Details and patient eligibility

About

This study aims to investigate whether preoperative NLR (Neutrophil-to-Lymphocyte Ratio) serves as a biomarker for PONV (Postoperative Nausea and Vomiting). It also examines the impact of erector spinae plane block on NLR and PONV. Furthermore, the research explores the effect of erector spinae plane block on postoperative pain relief in spinal surgery and its influence on the usage of opioid medications.

Enrollment: 220 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients undergoing elective posterior lumbar spine surgery in a prone position under general anesthesia.
2. ASA classification grades I to II.
3. Age between 18 and 80 years old.
4. Signed the informed consent for this study.

Exclusion criteria

1. Preoperative blood transfusion.
2. Uncontrolled systemic diseases.
3. Gastrointestinal system disorders.
4. History of antiemetic and anticholinergic drug use.
5. Adverse reactions related to surgery.
6. Severe spinal deformities.
7. Infection at the puncture site.
8. Coagulation disorders.
9. Long-term use of sedatives and analgesic drugs before surgery.
10. Patients with mental illness or communication barriers.
11. Allergic to ropivacaine.
12. Participants involved in other clinical studies within the past 3 months.
13. History of previous lumbar surgeries.
14. Subjective unwillingness to participate in this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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220 participants in 2 patient groups

Erector Spinae Plane Block group(EA group + EB group)

Experimental group

Description:

Conventional anesthesia induction, followed by ultrasound-guided erector spinae plane (ESPB) block with 0.5% ropivacaine (20 ml) after anesthesia induction.

Treatment:

Procedure: Erector Spinae Plane Block

Control group（CA group + CB group)

Sham Comparator group

Description:

Conventional anesthesia induction, followed by ultrasound-guided injection of 0.9% saline (20 ml) into the erector spinae plane (ESPB) after anesthesia induction.

Treatment:

Procedure: 0.9% physiological saline (20ml) injection under ultrasound-guided Erector Spinae Plane Block (ESPB).