The Relationship Between Peripheral Arterial Disease and Mitochondrial Respiratory Capacity

Norwegian University of Science and Technology

Status: Completed

Conditions: Intermittent Claudication

Study type: Observational

Funder types: Other

Identifiers

NCT02434783

2015/204

Details and patient eligibility

About

Current evidence cannot explain the clinical features of peripheral arterial disease only from the principle of reduced blood flow. Explanations have therefore in addition been linked to mitochondrial dysfunction of skeletal muscles.

This study will elucidate whether there is a relation between clinical variables of the different levels of arterial insufficiency in peripheral arterial disease and mitochondrial respiratory capacity.

Enrollment: 16 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Asymptotic peripheral arterial disease (Ankle-brachial index < 0.9), intermittent claudication (Ankle-brachial index 0.4 - 0.9), or critical limb ischemia (Ankle-brachial index < 0.4)

Exclusion criteria

• Diagnosed with intermittent claudication secondary to vascular insufficiency
• Warfarin or heparin usage
• Underwent a vascular intervention in the last 6 months
• Active cancer, renal- or liver disease

Trial design

16 participants in 4 patient groups

1st level of arterial insufficiency

Description:

asymptomatic PAD patients

2nd level of arterial insufficiency

Description:

Intermittent claudication patients

3rd level of arterial insufficiency

Description:

Critical limb ischemia patients

No arterial insufficiency

Description:

Healthy individuals (control)