The Relationship Between Postoperative Changes of Oral and Intestinal Flora and Prognosis

Harbin Medical University

Status

Unknown

Conditions

Oral Microbiota

Gut Microbiota

Colorectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT03667495

Yunwei Wei 2018-09-04

Details and patient eligibility

About

Specific oral microbiome has been found to contribute to the development of colorectal cancer. We speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment. This study aim to discover if any difference of oral microbiota exist in patients who suffer from cancer relapse compared with patients who do not. Finally develop patient-centred programmes of surveillance protocols base on microbiota analysis.

Full description

Colorectal cancer is a major cause of cancerrelated deaths and the third most commonly diagnosed cancer worldwide.Current estimates indicate that 20-30% of those who undergo treatment will experience recurrence and 35% of all patients will die within 5 years.

The human colon plays host to a diverse and metabolically complex community of microorganisms. While the specific oral microbiome has been found to contribute to the development of colorectal cancer. Investigators speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment.

Patients are routinely offered surveillance in order to detect disease recurrence at an early, asymptomatic stage, with the intention of improving survival. Nevertheless, controversy continues to surround the optimal surveillance protocols. Investigators aim to discover if any difference of oral microbiota is exist in patients who suffer from relapse compared with patients who do not.

Future surveillance after colorectal cancer treatment should focus on risk-stratification. Finally investigators will develop patient-centred programmes of surveillance protocols base on microbiota analysis.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Requirements of informed consent and assent of participant, parent or legal guardian as applicable
Patients who underwent exhaustive colorectal cancer surgical resection and accept colonoscopy
Patients between the age of 35 and 75 years old without considering sex
Patients with BMI= 18.5-23.9
Participants can follow the visit plan

Exclusion criteria

Patients with colorectal cancer with distant metastasis
Chronic renal diseases and hepatic cirrhosis
Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months
Individuals with a history of Chronic diarrhea
Individuals with a history of Diabetes mellitus
Individuals with a history of Hypertension
Individuals with a history of autoimmune diseases
Use of antibiotics and probiotics 3 mouth before samples collection
Individuals with a history of abdominal operation due to any reason
Individuals with any history of cancer other than colorectal cancer
Individuals with Inflammatory bowel disease