The Relationship Between Sarcopenia and Cardiovascular Disease in Chronic Kidney Disease and the Risk Involved.

Shanghai Jiao Tong University School of Medicine

Status: Completed

Conditions: CKD; Cardiovascular Diseases; Sarcopenia

Study type: Observational

Funder types: Other

Identifiers

NCT05479331

sarcopenia

Details and patient eligibility

About

This study explores the risk factors for sarcopenia in patients with chronic kidney disease and the effects of sarcopenia on cardiovascular disease. Treatment of sarcopenia and cardiovascular complications provides a basis for improving the quality of life and survival of patients with chronic kidney disease.

Full description

Sarcopeniais a syndrome characterized by the loss of skeletal muscle mass, muscle strength, and muscle dysfunction. The high incidence of sarcopenia in patients with chronic kidney disease (CKD) is strongly associated with poor quality of life, cardiovascular events, and increased all-cause mortality. At present, the cause of sarcopenia in patients with CKD is still unclear, and factors such as inflammation, malnutrition, and hormone metabolism disorders may affect the occurrence and development of sarcopenia. This topic explores the risk factors of sarcopenia in patients with chronic kidney disease and the correlation between sarcopenia and the risk of cardiovascular disease, and provides a basis for the prevention and treatment of sarcopenia and cardiovascular complications, with a view to improving the prognosis of CKD patients.

Enrollment: 120 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients presented by the Nephrology Center during August 2019 and March 2021
• Age 18-75 years;
• Patients with CKD2 or above (eGFR≤60 ml/(min 1.73m2)

Exclusion criteria

• There are contraindications to bioelectrical impedance spectroscopy (BIS) . examination, such as amputation, metal implants in the body, etc.;
• Complicated with other serious diseases, such as malignant tumors, cirrhosis, systemic infections, etc.

Trial design

120 participants in 2 patient groups

sarcopenia

Description:

CKD patients with sarcopenia, meeting the following two criteria (1) male LTI (lean tissue index)\< 7.0 kg/m2, female LTI \< 5.7 kg/m2; (2) Male HGS)(handgrip strength \< 26 kg, female HGS \< 18 kg.

non-sarcopenia

Description:

CKD patients with non-sarcopenia