The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

Turkish Ophthalmology Society

Status: Completed

Conditions: Behçet's Disease

Treatments: Other: serum levels of angiogenin, bFGF, VEGF

Study type: Observational

Funder types: Other

Identifiers

NCT01720628

AFV-5813

Details and patient eligibility

About

Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.

Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

Enrollment: 86 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 18-65
• fulfilling the international diagnostic criteria for Behçet's disease

Exclusion criteria

• to have another systemic disease

Trial design

86 participants in 1 patient group

Behçet's patients

Description:

Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group

Treatment:

Other: serum levels of angiogenin, bFGF, VEGF