The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers (Sleep GLP-1)

Mahidol University

Status: Completed

Conditions: Prediabetes

Treatments: Other: Oral glucose tolerance

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02229487

08-57-16

Details and patient eligibility

About

Hypothesis

1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration.
2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Enrollment: 51 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
2. Age 18 or older
3. Can understand Thai (speaking, listening and reading)
4. Agree to participate by written informed consent

Exclusion criteria

1. Those who depend on others for feeding (such as stroke patients)
2. Shift workers
3. History of congestive heart failure or low ejection fraction
4. Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
5. Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
6. Patients with permanent pacemaker
7. History of previous stroke

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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51 participants in 2 patient groups

Normal Sleepers

Active Comparator group

Description:

Prediabetes patients with normal sleep duration (7-8 hours/ night) as measured objectively

Treatment:

Other: Oral glucose tolerance

Short Sleepers

Experimental group

Description:

Prediabetes patients with short sleep duration (\<6 hours/night) as measured objectively

Treatment:

Other: Oral glucose tolerance