The Relationship Between the Neural Drive and Intrinsic Positive End-expiratory Pressure

Guangzhou Medical University

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: Resistance of the respiratory system

Study type: Interventional

Funder types: Other

Identifiers

NCT04840628

YLS2020(142)

Details and patient eligibility

About

To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.

Full description

To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.The diaphragm electromyogram (EMGdi) represents the neural drive to the diaphragm.A multi-pair esophageal electrode catheter was used to record the EMGdi.The PEEPi was assessed by the by the balloon-catheter in the multi-pair esophageal electrode catheter. In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive( EMGdi) was obtained from the a multi-pair esophageal electrode catheter All the signal recorded in the computer. The relation the nreural drive assessed by EMGdi and intrinsic positive end-expiratory pressure(PEEPi) would be analysed.

Enrollment: 10 patients

Sex: Male

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

chronic obstructive pulmonary disease patients with respiratory failure

Exclusion criteria

1. Heart failure
2. cardiac dysrhythmia
3. Loss of consciousness

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

neural respiratory drive

Experimental group

Description:

neural respiratory drive assessed by EMGdi recorded from a multipair esophageal electrode

Treatment:

Other: Resistance of the respiratory system