The Relationship Between the Residual Renal Function and Osteoporosis Treatment

Toshihiko Kono

Status: Unknown

Conditions: Osteoporosis

Treatments: Drug: Bis, SERM Teriparatide, Denosumab

Study type: Observational

Funder types: Other

Identifiers

NCT02304887

IRB TH No 9-1

Details and patient eligibility

About

The relationship between osteoporosis drugs and kidney damage is unclear. In this study, we plan to reveal relationship between osteoporosis drugs and kidney damage.

Full description

Chronic kidney disease (CKD)- mineral and bone disorder (CKD-MBD) is one of the topic in osteoporosis treatment. As many osteoporotic patients are older, many patients are under the deterioration of the renal function. In addition, several drugs might have the potential for kidney damage. But the relationship between osteoporosis drugs and kidney damage is unclear.

The main objective of this study is to reveal relationship between osteoporosis drugs and kidney damage.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Osteoporosis patients

Exclusion criteria

• eGFR < 15

Trial design

1,000 participants in 4 patient groups

Bisphosphonate

Treatment:

Drug: Bis, SERM Teriparatide, Denosumab

Selective estrogen receptor modulator

Treatment:

Drug: Bis, SERM Teriparatide, Denosumab

Teriparatide

Treatment:

Drug: Bis, SERM Teriparatide, Denosumab

Senosumab

Treatment:

Drug: Bis, SERM Teriparatide, Denosumab