The Relationship Between the Response to Mental Stress and Vascular Endothelial Function

Mayo Clinic

Status

Completed

Conditions

Apical Ballooning Syndrome

Myocardial Infarction

Coronary Endothelial Dysfunction

Study type

Observational

Funder types

Other

Other U.S. Federal agency

Identifiers

NCT00975559

1881-03

Details and patient eligibility

About

The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects. In one part of the study the investigators will compare the cardiovascular responses to mental stress between healthy women and healthy men. In another part of the study, the investigators will compare the cardiovascular responses to mental stress between women with apical ballooning syndrome and healthy post-menopausal women. The investigators hypothesize that healthy men will have an increased vascular response to and decreased endothelial function in response to to mental stress, compared to health women. Furthermore, the investigators hypothesize that women with apical ballooning syndrome will have an increased vascular response to and decreased endothelial function in response to mental stress.

Enrollment

190 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients must be identified in one of the four groups outlined in "study population description."

Exclusion criteria

Other co-morbidities that would make the testing not possible.
Women who have had a mastectomy and would not have an arm that could be occluded during the reactive hyperemia portion of the Peripheral arterial tonometry testing.