The Relationship Between Urine Iodine, Urine Bisphenol A and Autoimmune Thyroid Disease in Reproductive Women

Xiaomei Zhang

Status: Unknown

Conditions: The Effect of Iodine and BPA on AITD in Reproduction Women

Treatments: Other: urinary iodine and urine BPA

Study type: Observational

Funder types: Other

Identifiers

NCT03932487

Peking UIH

Details and patient eligibility

About

Autoimmune thyroid disease (AITD) is the main cause of hypothyroidism in reproduction women, iodine and bisphenol A are the environmental factors for AITD. The research was mainly designed to investigate the effect of iodine and BPA on AITD in reproduction women to provide new evidence for hypothyroidism in reproduction women.

Full description

71 patients with thyroid autoantibody positive were treated as AITD group, another 71 healthy reproduction women were selected as normal group. Women age, BMI, thyroid disease history, family history, marital and reproductive history, whether the application of iodized salt, thyroid function and thyroid autoantibodies detection were recorded. Meanwhile urine iodine, urinary iodine/urinary creatinine, urine BPA and urinary BPA/creatinine were tested. The urine iodine and BPA levels of the two groups were compared. Taking AITD as the dependent variable, logistic regression was conducted to analyze whether urinary iodine and BPA were risk factors of AITD.

Enrollment: 142 estimated patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. AITD group: positive thyroid autoantibody (one thyroid autoantibody), normal thyroid function.
2. Normal group: thyroid autoantibody negative, normal thyroid function.
3. No previous history of hyperthyroidism or hypothyroidism, no history of thyroid surgery or I131 radiotherapy, and no thyroid hormone or anti-thyroid drugs were used.

Exclusion criteria

1. Patients with severe liver, kidney, heart and other important organ failure.
2. Merger with other autoimmune diseases.
3. Amiodarone, iodine contrast agent and other drugs affecting thyroid function are used.

Trial design

142 participants in 2 patient groups

AITD group

Description:

Thyroid antibody positive and hypothyroidism

Treatment:

Other: urinary iodine and urine BPA

normal group

Description:

Thyroid antibody negative and hypothyroidism

Treatment:

Other: urinary iodine and urine BPA