The Relationship Between Vitamin D and Hepatitis B Virus Replication

Buddhist Tzu Chi Medical Foundation

Status: Completed

Conditions: Vitamin D and Hepatitis B Virus

Treatments: Dietary Supplement: Vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT03068767

TZ-105

Details and patient eligibility

About

149 HBV carriers with inadequate serum vitamin D levels were randomized to two groups: one is supplied with vitamin D and another without as controls. The markers of HBV replication were compared before and after treatment.

Full description

This is a randomized case-control trial. A total of 149 HBV carriers with inadequate vitamin D (< 30 ng/mL) level were enrolled. They were randomly divided to two groups: one group receiving vitamin D supplement (1600 IU/day) for 2 months and another group as controls. The serum vitamin D, HBV DNA and qHBsAg levels were measured at baseline and after vitamin D supplement. Whether HBV DNA and qHBsAg have significant change after vitamin D supplement can be determined.

Enrollment: 149 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• >20 y/o, HBV carrier
• serum vitamin D < 30ng/ml

Exclusion criteria

• Other known causes of hepatitis

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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149 participants in 2 patient groups

Vitamin D group

Experimental group

Description:

Patients receiving vitamin D supplement (2000 IU/day) for 2 months

Treatment:

Dietary Supplement: Vitamin D

Control group

No Intervention group

Description:

Patients without receiving vitamin D supplement