The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

National Center for Research Resources (NCRR)

Status and phase: Completed; Phase 1

Conditions: Osteoporosis

Treatments: Drug: Vitamin D

Study type: Interventional

Funder types: NIH

Identifiers

NCT00006196

NCRR-M01RR00036-0754

M01RR000036 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. An unknown number of elderly have vitamin D resistance resulting in a functional vitamin D deficiency state. Because there are no simple procedures or blood tests that identify vitamin D resistance, its prevalence and contribution to disability in the elderly is unknown. Our inability to screen for this condition precludes our ability to initiate and monitor treatment.

Previous studies indicate that fingernail thickness correlates with vitamin D status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin D deficiency but also, those with vitamin D resistance. This procedure may also provide a way to monitor an individual's response to treatment.

This study is designed to demonstrate the association between fingernail thickness and vitamin D status.

Sex: Female

Ages: 25 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• females 25-75 years of age with no known bone disorders

Exclusion criteria

• history of vertebral fractures or nonvertebral fractures without trauma
• prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen)
• history of malignancy other than basal cell or squamous cell cancer of the skin
• use of steroids or anticonvulsants in the 6 months prior to enrollment