The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection

Fatih Sultan Mehmet Training and Research Hospital

Status: Completed

Conditions: Vitamin D Deficiency; Covid19

Treatments: Other: 25 OH Vitamin D Level; Diagnostic Test: Inflammatory Parameters

Study type: Observational

Funder types: Other

Identifiers

NCT04945577

Gulcanozturk

Details and patient eligibility

About

Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.

Full description

In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded

Enrollment: 300 patients

Sex: All

Ages: 16 to 97 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months

Exclusion criteria

• Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study

Trial design

300 participants in 3 patient groups

Experimental: Mild Clinical Group

Description:

patients showing mild clinical symptoms without pneumonia.

Treatment:

Diagnostic Test: Inflammatory Parameters

Other: 25 OH Vitamin D Level

Experimental: Moderate Clinical Group

Description:

patients with fever, other respiratory symptoms, and pneumonia findings based on radiological imaging

Treatment:

Diagnostic Test: Inflammatory Parameters

Other: 25 OH Vitamin D Level

Experimental: severe/critical clinical group

Description:

severe one of these as follows; patients with hypoxia (≤93% oxygen saturation), respiratory distress (RR >30 times per minute), partial pressure of arterial blood oxygen (PaO 2 )/the fraction of inspired oxygen (FiO 2 ) ≤ 300 mmHg, patients whose chest imaging shows that lung damage develops significantly within 24 to 48 hours, or critical one of these as follows; respiratory failure requiring mechanical ventilation, signs of septic shock with multiple organ failure requiring intensive care unit admission.

Treatment:

Diagnostic Test: Inflammatory Parameters

Other: 25 OH Vitamin D Level