The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection

F

Fatih Sultan Mehmet Training and Research Hospital

Status

Completed

Conditions

Vitamin D Deficiency
Covid19

Treatments

Other: 25 OH Vitamin D Level
Diagnostic Test: Inflammatory Parameters

Study type

Observational

Funder types

Other

Identifiers

NCT04945577
Gulcanozturk

Details and patient eligibility

About

Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.

Full description

In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded

Enrollment

300 patients

Sex

All

Ages

16 to 97 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months

Exclusion criteria

Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study

Trial design

300 participants in 3 patient groups

Experimental: Mild Clinical Group
Description:
patients showing mild clinical symptoms without pneumonia.
Treatment:
Diagnostic Test: Inflammatory Parameters
Other: 25 OH Vitamin D Level
Experimental: Moderate Clinical Group
Description:
patients with fever, other respiratory symptoms, and pneumonia findings based on radiological imaging
Treatment:
Diagnostic Test: Inflammatory Parameters
Other: 25 OH Vitamin D Level
Experimental: severe/critical clinical group
Description:
severe one of these as follows; patients with hypoxia (≤93% oxygen saturation), respiratory distress (RR >30 times per minute), partial pressure of arterial blood oxygen (PaO 2 )/the fraction of inspired oxygen (FiO 2 ) ≤ 300 mmHg, patients whose chest imaging shows that lung damage develops significantly within 24 to 48 hours, or critical one of these as follows; respiratory failure requiring mechanical ventilation, signs of septic shock with multiple organ failure requiring intensive care unit admission.
Treatment:
Diagnostic Test: Inflammatory Parameters
Other: 25 OH Vitamin D Level

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems