The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations

Trakya University

Status

Completed

Conditions

Craniotomy

Antiepileptic Drugs

Metabolic Acidosis

Anesthesia Management

Treatments

Procedure: Arterial Blood Gas Base Deficit

Study type

Observational

Funder types

Other

Identifiers

NCT05940935

TÜTF-GOBAEK 2023/210

Details and patient eligibility

About

The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations

Full description

Metabolic acidosis is a life-threatening complication in the perioperative, intraoperative and postoperative period. It can cause decreased cardiac output, electrolyte imbalance, surgical bleeding and neurological complications, even coma and death in surgical patients.

Topiramate and zonisamide are sulfonamide derivative compounds used in the treatment of epilepsy. It has been shown in studies that both drugs have a strong inhibition of carbonic anhydrase enzyme. Recent case reports suggest that both drugs may cause metabolic acidosis by lowering serum bicarbonate levels in some patients.

Aim in this study is to determine the relationship between preoperative, intraoperative and postoperative metabolic acidosis and to emphasize the importance of anesthesia management in patients who have undergone craniotomy and use antiepileptic drugs.

Enrollment

35 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients undergoing intracranial surgery with craniotomy and using antiepileptic drugs
ASA I-III
Patients undergoing elective surgery

Exclusion criteria

Patients with a surgical procedure time of more than 5 hours
Patients who received more than 2 units of blood transfusion during the operation
Patients taking other drugs that can cause metabolic acidosis
Patients with diabetes mellitus, diabetes insipidus, hepatic or renal disease