The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia

Second Affiliated Hospital of Wenzhou Medical University

Status: Completed

Conditions: Preeclampsia; Estrogen; Progestin; Phthalate Exposure

Treatments: Other: test Phthalates, estrogen and progesterone

Study type: Observational

Funder types: Other

Identifiers

NCT04777929

SAHoWMU-CR2020-07-210

Details and patient eligibility

About

Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Singleton pregnancy
• Term pregnancy with the gestational age of 37-40 weeks

Exclusion criteria

• Maternal systemic diseases (hypertension disorders, immunological diseases) or pregnant complications (polyhydramnios, oligohydramnios, diabetes mellitus, intrahepatic cholestasis of pregnancy)
• Delivery before 37 weeks or after 40 weeks

Trial design

60 participants in 2 patient groups

healthy pregnant woman

Description:

pregnant woman without any disease of pregnancy

Treatment:

Other: test Phthalates, estrogen and progesterone

pregnant woman with preeclampia

Description:

pregnant woman with preeclampia but without any other disease of pregnancy

Treatment:

Other: test Phthalates, estrogen and progesterone