The Relationship of Sevoflurane Consumption With Metabolic Age

Inonu University

Status: Completed

Conditions: Sevoflurane

Treatments: Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

Study type: Observational

Funder types: Other

Identifiers

NCT06018597

Inonu 2022/92

Details and patient eligibility

About

The aim of this clinical study is to determine the consumption of sevoflurane, which is one of the inhalation anesthetics, with metabolic age and basal metabolic rate. The basal metabolic rates and metabolic ages of the patients who will be given sevoflurane- maintained general anesthesia were measured preoperatively. The relationship between the amount of sevoflurane consumption and the measured data of the patients in the postoperative period was examined.

Full description

Standard monitoring, BIS, TOF (train of four) were performed from the premedication application. Aspect A 2000 (Aspect Medical Systems, Newton) monitor and single-chip BIS electrodes will be used for BIS. The total amount of sevoflurane consumed and MAK values of these components will be recorded. Chronological age, metabolic age, BMR, height, weight, ideal body weight, BMI, body adiposity, body fluid ratio, body fluid care, fat mass, lean body weight, muscle registered, visceral adiposity, obesity degree in the preoperative period of the patients. Values, ASA scores and demographic data will be recorded for the operation process, cutting time, anesthesia time, extubation time, total sevoflurane consumption throughout the case, and the relationship with basal metabolism and metabolic age will be evaluated.

Enrollment: 79 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Between the ages of 18-65 who are scheduled for rhinoplasty or septoplasty with ASA I-II Cases lasting 1 to 3 hours

Exclude Criteria:

Patients at high risk of malignant hyperthermia, with a history of allergy to general anesthesia or any of the drugs to be used in the study, accepted as ASA III- ASA IV

Trial design

79 participants in 3 patient groups

percent age difference < -6.6%

Description:

The percentage age difference in the negative direction represents patients whose metabolic age is greater than their chronological age. When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. This group refers to those whose percentage age difference is less than -6.6%

Treatment:

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

percent age difference -6.6% to 11.7% those between

Description:

When we analyze the ROC analysis in the negative direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percentage age difference is -6,6%. When we analyze the ROC analysis in the positive direction, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference between -6.6% and 11.7%

Treatment:

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL

percent age difference > 11.7%

Description:

the percent age difference in the positive direction represents patients whose metabolic age is less than their chronological age. When we analyze the ROC analysis in the positive direction,between Percent Age Difference and Sevoflurane Consumption Amount Calculated According to Metabolic Age, the cut-off value of the percent age difference is 11.7%. This group refers to those whose percentage age difference is more than 11.7%

Treatment:

Drug: Sevoflurane Baxter, 100%, Inhalation Vapour, Liquid 250 mL