The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis

Hui Bu

Status and phase: Unknown; Phase 4

Conditions: Tuberculous Meningitis

Treatments: Drug: Dexamethasone acetate

Study type: Interventional

Funder types: Other

Identifiers

NCT02588196

BH 002

Details and patient eligibility

About

The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.

Enrollment: 200 estimated patients

Sex: All

Ages: 14+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients were eligible to enter the study if they met the diagnositic criteria for possible, probable or definite Tuberculosis meningitis(TBM).

Exclusion criteria

Patients were excluded if they were infected with HIV, diagnosed as carcinomatous meningitis, viral meningitis, purulent meningitis, cryptococcus meningitis.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

treatment of dexamethasone group

Experimental group

Treatment:

Drug: Dexamethasone acetate