The Relationships Between the Noradrenergic, Opioid and Pain System

Rambam Health Care Campus

Status: Withdrawn

Conditions: Experimental Pain Perception

Treatments: Other: saline; Drug: placebo; Drug: Naloxone; Drug: Clonidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01851486

0393-12-RMB.CTIL

Details and patient eligibility

About

The role of alpha2 receptor agonist on pain perception and modulation will be examined. In addition whether this is mediated through the opioid system will be examined. Pain perception and modulation will be examined before and after administration of Clonidine or placebo together with Naloxone or saline.

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Age 18-40
• No chronic disease

Exclusion criteria

• Subjects who suffer from chronic pain / pain syndrome
• use of anti-depressant or anti-psychotic drugs
• suffering from cardiovascular disease
• breast feeding

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 4 patient groups, including a placebo group

Clonidine+ Saline

Active Comparator group

Description:

Clonidine 0.15 mg and saline 0.15 mg/kg

Treatment:

Other: saline

Drug: Clonidine

Clonidine + Naloxone

Active Comparator group

Description:

Clonidine 0.15 mg and Naloxone 0.15 mg/kg

Treatment:

Drug: Clonidine

Drug: Naloxone

Placebo +Naloxone

Active Comparator group

Description:

Placebo 0.15 mg+ naloxone 0.15 mg/kg

Treatment:

Drug: placebo

Drug: Naloxone

Placebo +saline

Placebo Comparator group

Description:

Placebo 0.15 mg+ saline 0.15 mg/kg

Treatment:

Other: saline

Drug: placebo