The Renin-Aldosterone Axis in Postural Tachycardia Syndrome

Vanderbilt University Medical Center

Status and phase: Completed; Phase 1

Conditions: Postural Orthostatic Tachycardia Syndrome (POTS)

Treatments: Drug: Angiotensin II

Study type: Interventional

Funder types: Other

Identifiers

NCT00962949

081398

PF334

Details and patient eligibility

About

The purpose of this study is to determine the role of the renin-angiotensin-aldosterone in the pathophysiology of postural tachycardia syndrome, and to provide an insight about the disease process in this disorder.

Enrollment: 28 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of postural tachycardia syndrome by the Vanderbilt Autonomic Dysfunction Center criteria
• Age between 18-64 years
• Male or females are eligible
• Able and willing to provide informed consent
• Healthy control subjects with no major medical problem (including postural tachycardia syndrome), free of medications during the study

Exclusion criteria

• Overt cause of postural tachycardia e.g., dehydration
• Inability to give or withdraw informed consent
• Pregnancy
• Hypertension (BP > 140/90)
• Significant co-morbid condition
• Other factors which in the investigator's opinion would prevent the subject from completing the protocol

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

28 participants in 2 patient groups

Control

Experimental group

Description:

Healthy controls

Treatment:

Drug: Angiotensin II

Postural Tachycardia Syndrome

Experimental group

Description:

Patients with Postural Tachycardia Syndrome

Treatment:

Drug: Angiotensin II