The Renin-Angiotensin System in Essential Hypertension

St George's, University of London

Status: Terminated

Conditions: Hypertension

Treatments: Drug: Candesartan 8 mg bd; Drug: Enalapril 20 mg bd

Study type: Interventional

Funder types: Other

Identifiers

NCT00141583

LREC 01.87.10

Details and patient eligibility

About

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Enrollment: 11 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Essential Hypertension
• SBP 140-159 mmHg
• DBP 90-99 mmHg

Exclusion criteria

• Intolerance of or allergy to ACE Inhibitors or ARBS
• Pregnant or Breastfeeding
• Pre-menopausal women
• Uncontrolled cardiac or renal failure
• Diabetes mellitus