The Research of Metabolomics on COPD

Guangzhou Institute of Respiratory Disease

Status: Completed

Conditions: Metabolomics; Omega 3; Omega 6; COPD

Treatments: Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.; Diagnostic Test: Routine blood test; Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Study type: Observational

Funder types: Other

Identifiers

NCT04042519

MG-201909

Details and patient eligibility

About

Targeted metabolomics research was conducted on patients with chronic obstructive pulmonary disease (COPD). The correlation analyst between inflammation-related metabolites and lung function was analyzed by explored the metabolic pathways of inflammation-related omega-6 and omega-3 and combining them with lung function.

Full description

Based on the global initiative for chronic obstructive pulmonary disease, the 80 confirmed stable COPD patients with mild-to-moderate were involved, 80 COPD patients with severe and very severe, and age, sex, all matching 40 cases without lung disease. The participants information was collected. Whole blood and pulmonary function were examined at three time points: admission, six months and one year, at the same time, targeted metabolomic analysis method are applied to detect serum metabolites, According to the access to assess the different severity of COPD in the stable period and the level of metabolites in different admission periods. After that, correlation analysis was conducted with pulmonary function indicators and other clinical indicators to observe the research value of inflammation-related metabolites in the development of COPD.

Enrollment: 200 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD diagnosis
• The age ranges from 40 to 80
• No other pulmonary diseases
• No immune-related diseases

Exclusion criteria

• Not consistent with COPD diagnosis
• Age is out of range
• Interstitial lung disease, asthma and other lung diseases
• Immune system diseases
• Lost to follow-up

Trial design

200 participants in 6 patient groups

Healthy control

Description:

age - and sex-matched healthy individuals without lung disease

Treatment:

Diagnostic Test: Routine blood test

Patients with mild and moderate COPD

Description:

Grading according to the GOLD guide standards

Treatment:

Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

Diagnostic Test: Routine blood test

Patients with severe and very severe COPD

Description:

Grading according to the GOLD guide standards

Treatment:

Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

Diagnostic Test: Routine blood test

The severe and very severe COPD group baseline

Description:

Severe and very severe COPD patients were in the baseline time group

Treatment:

Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

Diagnostic Test: Routine blood test

The severe and very severe COPD group six months

Description:

Patients with severe and very severe COPD were six months from baseline.

Treatment:

Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

Diagnostic Test: Routine blood test

The severe and very severe COPD group one year

Description:

Patients with severe and very severe COPD were one year from baseline.

Treatment:

Diagnostic Test: Lung function test was performed on the subjects with Jaeger lung function instrument of Germany.

Diagnostic Test: Agilent 1290 Infinity LC system (UHPLC, Santa Clara CA) was used for Targeted metabolite detection.

Diagnostic Test: Routine blood test