The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis

Zhejiang University

Status and phase: Completed; Phase 4

Conditions: Chronic Periodontitis

Treatments: Procedure: surface and root planning; Drug: minocycline

Study type: Interventional

Funder types: Other

Identifiers

NCT02355977

2013-25

Details and patient eligibility

About

To evaluate the respective or combinatory efficacy of locally delivered 2% Minocycline (MO) and surface and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis.

Full description

In this randomized clinical trial, the investigators will evaluate the respective or combinatory efficacy of minocycline and scaling and root planning in the aspects of both clinical parameters [Pocket depth (PD) and sulcus bleeding index (SBI)] and the loads of four main periodontal pathogens [Aggregatibacter actinomycetemcomitans (Aa), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg) and Prevotella intermedia (Pi)]. Real-time quantitative PCR (qRT-PCR) will be used as a powerful tool with high sensitivity and specificity to quantitatively assess target periodontal bacteria in a period of 7 days. The investigators will also try to correlate the reduction of either total or respective bacteria with the improvements of clinical parameters, with an aim to uncovering the potential microbiological mechanism accounting for the efficacy of a therapy.

Enrollment: 70 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed with moderate or severe chronic periodontal disease, and exhibited bleeding on probing and attachment loss, with radiographic alveolar bone loss in four or more teeth

Exclusion criteria

• pregnant, had used antibiotics within the last 3 months, had periodontal therapy in the past 6 months or had systemic diseases such as heart disease or hypertension

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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70 participants in 3 patient groups

surface and root planning

Active Comparator group

Description:

surface and root planning is performed in a single-visit, one-stage, full mouth pattern using periodontal ultrasonic scaler (Satelec, Mérignac, France)

Treatment:

Procedure: surface and root planning

locally delivered minocycline

Active Comparator group

Description:

Locally delivered minocycline is administered directly into the periodontal pocket up to the gingival margin of the selected teeth

Treatment:

Drug: minocycline

Procedure: surface and root planning

surface and root planning+minocycline

Experimental group

Description:

surface and root planning+locally delivered minocycline is the combined administration of both surface and root planning and locally delivered minocycline.

Treatment:

Drug: minocycline