The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery

Tampere University Hospital

Status

Completed

Conditions

Heart; Decompensation, Right Ventricle

Hypercapnia

Echocardiography

Treatments

Procedure: Hypercarbia

Study type

Interventional

Funder types

Other

Identifiers

NCT02757573

R16005

Details and patient eligibility

About

Full description

The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.

Enrollment

31 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

scheduled mitral valve prolapse repair surgery
able to give informed consent

Exclusion criteria

preoperative right ventricular dysfunction or pulmonary hypertension
significant tricuspid regurgitation
congenital heart defect
ventricular dyssynchrony or wide QRS-complex on ECG (> 130 ms)
prior myocardial infarction (within tree months) or pericardial constriction
preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 %
if the scheduled repair by plastic procedure has been converted to mitral valve replacement