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The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery

T

Tampere University Hospital

Status

Completed

Conditions

Heart; Decompensation, Right Ventricle
Hypercapnia
Echocardiography

Treatments

Procedure: Hypercarbia

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.

Full description

The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.

Enrollment

31 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • scheduled mitral valve prolapse repair surgery
  • able to give informed consent

Exclusion criteria

  • preoperative right ventricular dysfunction or pulmonary hypertension
  • significant tricuspid regurgitation
  • congenital heart defect
  • ventricular dyssynchrony or wide QRS-complex on ECG (> 130 ms)
  • prior myocardial infarction (within tree months) or pericardial constriction
  • preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 %
  • if the scheduled repair by plastic procedure has been converted to mitral valve replacement

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

31 participants in 1 patient group

Hypercarbia
Experimental group
Description:
Hypercarbia: PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation.
Treatment:
Procedure: Hypercarbia

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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