The Risk Factors for Acute Radiation Pneumonitis in Patients With Prior Receipt of Immune Checkpoint Inhibitors

Hubei Cancer Hospital

Status: Enrolling

Conditions: Cancer Patients

Treatments: Radiation: Cancer patients underwent thoracic intensity-modulated radiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT05219851

HBCH-RT-2022-RP

Details and patient eligibility

About

The purpose of this non-interventional study is to collect data on the risk factors for acute radiation pneumonitis in patients with prior receipt of immune checkpoint inhibitors.

Full description

1. Incidence of acute radiation pneumonitis (aRPs) in in patients with prior receipt of immune checkpoint inhibitors.
2. Risk factors (especially analysis of the dosimetric risk factor) which may affect the product of aRPs events.
3. Establish a model to predict aRPs and guide clinical treatment.

Enrollment: 250 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Pathologically or cytologically confirmed malignant tumor
2. Cancer patients with previously received ICIs underwent thoracic intensity-modulated radiotherapy

Exclusion criteria

1. Cancer patients did not receive immunotherapy before thoracic intensity-modulated radiotherapy
2. Non-thoracic radiotherapy patients