The Risk of Adverse Pregnancy Outcomes for Long-term Exposure to Air Pollution in Pregnant Patients With Pulmonary Hypertension

Wei Huang

Status: Completed

Conditions: Maternal Outcome; Air Pollution; Pulmonary Arterial Hypertension

Study type: Observational

Funder types: Other

Identifiers

NCT07164157

2025XMSB0000311

Details and patient eligibility

About

With economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have specifically examined the impact of environmental factors on pulmonary hypertension in pregnant women, nor their subsequent birth outcomes. Therefore, investigating the correlation between them holds substantial clinical and public health significance.

Full description

The purpose of the research is preliminary found that the correlation between air pollution and maternal outcomes in pregnant women with pulmonary arterial hypertension and provide useful information for managment of pregnant women in special ambient conditions.

Enrollment: 1,200 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pregnant women with pulmonary hypertension who attended major medical centers included in this study from January 2013 to December 2022.

  • Complete medical records available; ② Pulmonary artery systolic pressure ≥ 35 mmHg by echocardiography or a confirmed diagnosis of pulmonary hypertension by right heart catheterization; ③ Residential address information available at the city (district, county) level or higher.

Exclusion criteria

• ① Unclear diagnosis and completely missing address information;

  • Incomplete medical records; ③ Lost to follow-up during pregnancy or within six weeks postpartum.

Trial design

1,200 participants in 24 patient groups

The First Affiliated Hospital of Chongqing Medical University

The Second Affiliated Hospital of Chongqing Medical University

Xiangya Hospital of Central South University

The second Xiangya Hospital of Central South University

Yan'an Hospital of Kunming City

Gansu Provincial Hospital

Qilu Hospital of Shandong University

The second hospital of Army Military University

Guizhou Provincial People's Hospital

The Second Affiliated Hospital of Nanchang University

Henan Provincial People's Hospital

Gannan Medical University

Women and Children's Hospital of Chongqing Medical University

The First People's Hosipital of Yunnan Province

People's Hosipital of Xinjiang Uygur Autonomous Region

The First Affiliated Hospital of Anhui Medical University

Yantai Yuhuangding Hospital

The Third People's Hosipital of Chengdu

Zhongda Hospital Southeast University

The First Affiliated Hospital of Xi'an Jiao Tong University

Gansu Provincial Maternity and Child-care Hospital

The First Affiliated Hospital of Guangxi Medical University

Xijing Hospital

Shenzhen People's Hospital