The ROAR Study: Reactive Oxygen Species and Reproduction

University of California San Francisco (UCSF)

Status: Not yet enrolling

Conditions: Ovarian Aging; Oxidative Stress; IVF Outcome

Treatments: Diagnostic Test: Oxidative stress markers

Study type: Observational

Funder types: Other

Identifiers

NCT06831019

24-42357

Details and patient eligibility

About

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Enrollment: 1,100 estimated patients

Sex: All

Ages: 18 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Female age 18-43 years
2. Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
3. Male partners 18 years of age or older.

Exclusion criteria

• Female partner age 44 or older
• Planning fresh transfer (hybrid PGS cycle)
• Cleavage stage biopsy

Trial design

1,100 participants in 1 patient group

Couples undergoing IVF

Description:

Heterosexual couples undergoing IVF

Treatment:

Diagnostic Test: Oxidative stress markers