The Role of Aldosterone in Circulatory Disorders Within Type 2 Diabetes

University of Southern Denmark (SDU)

Status: Completed

Conditions: Endothelial Dysfunction; Insulin Resistance

Treatments: Drug: Eplerenone

Study type: Interventional

Funder types: Other

Identifiers

NCT03017703

H- 15007940

Details and patient eligibility

About

The importance of Aldosterone for endothelial function and Insulin resistance observed within patients with type 2 diabetes

Enrollment: 27 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosed diabetic < 5 Yrs.
• BMI < 32 kg/m2
• Non-smoking
• Blood pressure < 140/90 mmHg (treatment with maximum of two antihypertensive drugs)

Exclusion criteria

• Insulin treatment
• Hypertension (>140/90 mmHg)
• Sequelae to diabetes
• Smoking
• Known chronic diseases
• Pregnancy or birth within 3 month
• Alcohol misuse

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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27 participants in 2 patient groups

Type 2 Diabetes

Experimental group

Description:

8 weeks of treatment with Aldosterone blocker Eplerenone

Treatment:

Drug: Eplerenone

Healthy

Experimental group

Description:

8 weeks of treatment with Aldosterone blocker Eplerenone

Treatment:

Drug: Eplerenone