The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

China Medical University

Status: Unknown

Conditions: Sick Sinus Syndrome

Treatments: Other: observation

Study type: Observational

Funder types: Other

Identifiers

NCT01310920

DMR99-IRB-316

Details and patient eligibility

About

Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Enrollment: 400 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• sick sinus syndrome

Exclusion criteria

• 1.Severe systemic disease.
• 2.Acute coronary syndrome.
• 3.bradycardia with reversible cause.

Trial design

400 participants in 2 patient groups

sick sinus syndrome

Treatment:

Other: observation

control