The Role of Cathepsin X in Infection With the Helicobacter Pylori

University Medical Centre Ljubljana

Status: Unknown

Conditions: Persistence of Infection With Helicobacter Pylori

Treatments: Drug: clarithromycin, metronidazole, proton pump inhibitor

Study type: Observational

Funder types: Other

Identifiers

NCT01137942

IMI2010-1

1000-05-310123 (Other Grant/Funding Number)

Details and patient eligibility

About

The immune response to Helicobacter pylori (Hp) importantly determines the pathogenesis of infection as well as the success of antibiotic eradication of the bacteria. The investigators want to demonstrate the importance of cathepsin X (CTSX), a cysteine protease, for the Hp eradication success. The diversity of the innate immune response to H. pylori antigens leading to either successful eradication of the infection or maintenance of chronic inflammation is connected to CTSX. The aim of this study is to determine whether H. pylori suppresses the CTSX expression and cytokine secretion in macrophage cell line THP-1 in the individuals that are not capable of eradicating the infection, opposite to H pylori in patients with successful H pylori eradication . The investigators also investigate the possibility whether strain-dependent differences in H. pylori lipopolysaccharide (LPS) influence the CTSX expression and cytokine secretion.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:People with helicobacter gastritis and Helicobacter sensitive to antibiotic therapy but failure of therapy -

Exclusion Criteria:People with helicobacter gastritis who did not eradicate Helicobacter pylori because of primary resistance to antibiotics.

Trial design

14 participants in 1 patient group

H. pylori eradication failure

Description:

Those who eradicated Helicobacter pylori with appropriate antibiotic therapy and those who did not.

Treatment:

Drug: clarithromycin, metronidazole, proton pump inhibitor